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The CZECANCA Consortium has been created for the association of diagnostic and research laboratories that are using the CZECANCA panel for the diagnosis of high-risk cancer patients. Today, it represents a national platform of genetic laboratories sharing phenotype and genotype data and creating a common database.

The consortium aims:

• Data sharing for the development of anonymized database of genotypes and phenotypes in high-risk individuals and non-cancer controls analyzed by the CZECANCA panel,


• Functional characterization of selected VUS variants,


• Organization of regular workshops aiming at a unified interpretation of genotypes in Czech patients,


• Co-ordination of activities in international consortia (ENIGMA, CIMBA, BCAC, OCAC, ECAC).

	Participating laboratories:	Contacts (activities):
001	First Faculty of Medicine, Charles University and General University Hospital in Prague	Zdeněk Kleibl (consortium co-ordination, international consortia) Jana Soukupová (panel development, international consortia) Markéta Janatová (variant consensus, international consortia) Petra Zemánková (bioinformatics, database) Petra Kleiblová (RNA analyses, international consortia) Marianna Borecká (laboratory and data analysis) Michal Vočka (clinical genetics, database curation) Ondřej Havránek (clinical genetics) Jan Novotný (clinical genetics)
002	Masaryk Memorial Cancer Institute (MMCI) in Brno	Eva Macháčková (aboratory and data analysis, variant consensus) Lenka Foretová (genetic counseling, criteria adjustment)
003	AGEL laboratories	Spiros Tavandzis (laboratory and data analysis) Věra Krutílková (clinical genetics)
004	GENNET	Moika Koudová (clinical genetics) Štěpán Chvojka (variant consensus)) Leona Černá (laboratory and data analysis)
008	GHC Genetics, s.r.o.	Mgr. Helena Paszeková (laboratory and variant analysis) Renáta Michalovská (laboratory and data analysis) Zdeňka Vlčková (clinical genetics)
009	Faculty Hospital in Pilsen	Monika Černá (laboratory and data analysis) Ivan Šubrt (clinical genetics)
011	Pronatal	Marcela Kosařová (laboratory and data analysis)
012	Faculty Hospital in Olomouc	Mária Janíková (laboratory and data analysis)
013	Hospital České Budějovice	Ondřej Scheinost (laboratory and data analysis) Petra Dušková (laboratory and data analysis)
014	PRENET	Miroslav Fišer (laboratory and data analysis)
015	Ústav klinické a molekulární patologie a lékařské genetiky, FN Ostrava	Mgr. Lucie Faldynová (data analysis)
016	Genetika Plzeň	Mgr. Michaela Nečesánková,PhD (data analysis)
	Other collaborators:	Contact (activities):
	Laboratory of Cancer Cell Biology, IMG Czech Academy of Sciences	Libor Macůrek (functional analyses in vitro)
	Department of Pediatrics and Inherited Metabolic Disorders (KPDPM)	Viktor Stránecký (bioinformatics, databases) Petr Nehasil (bioinformatics, databases, web)

CZECANCA users’ workshops:

The workshops serve for regular exchange of users’ experiences with panel analysis, bioinformatics, and clinical interpretation of genetic variants. The workshops become an important platform for laboratory workers, bioinformaticians, clinical geneticists, and oncologists to unify/update national guidelines for germline genetic testing of cancer predisposition and to unify/discuss further development of care of mutation carriers in Czechia. Many activities exceeding the scope of germline genetic testing are realized in cooperation with other healthcare professionals as well as with national healthcare professional societies including the Czech Society for Medical Genetics and Genomics and Czech Society for Oncology



12. workshop (12. workshop (2024-05-16; Praha, 1. LF UK)





11. workshop (11. workshop (2023-02-14; Praha, 1. LF UK)





10. workshop (2022-05-17; České Budějovice, National conference of DNA diagnostics)





9. e-workshop (2021-11-30; on-line)





8. workshop (2021-06-09; Praha, 1. LF UK)





7. e-workshop (2020-11-10; on-line)





6. workshop (2019-12-12; Praha, IMG CAS)





5. workshop (2019-05-23; Plzeň, FN Plzeň)





4. workshop (2018-10-18; Ostrava, AGEL)





3. workshop (2018-02-13; Praha, 1. LF UK)





2. workshop (2017-05-15; Praha, GENNET)





1. workshop (2016-09-19; Brno, MMCI)